I'm a sub and I suffer from Major Depressive Disorder. My submission only extends to sexual activities (the rest of the time, I'M in charge), so I'd feel if I were in a D/s situation all the time. For me, I find that the worse my depression is, the more likely it is that I'm going to want gentle, vanilla sex. Of course 99% of the time, I'm not going to want sex if I'm depressed.

My hubby is a dominant-leaning switch (mostly dom because I'm sub). He has Borderline Personality Disorder. The erratic nature of Borderline may have something to do with why he's a switch. It certainly keeps my sex life interesting - he's always coming up with ideas for new things for us to do.