The minor stuff is easy to over look but when it comes to trying to read through the story it loses it's appeal. Formating of the story is another problem I have, font size, color, it all leads to ease in reading.
I'm not the best at grammar so I try and give people a break but if you know you have an issue, ask for help. There a lot of friendly and helpful people here who I am sure wouldn't give it a second thought to proof a story.