To use your motorcycle example I'm not arguing for attaching the helmet to the motorcycle or having it come with the motorcycle I'm arguing for not abolishing the law that requires helmets.
As for suffering, it is pretty clear to me that rules that mitigate the suffering caused by unscrupulous or negligent actions do far less harm to the general populous than the suffering that is caused when those rules are not in place or enforced.
Regarding the mining fraud it was a historic event, regarding loopholes it does happen all the time. Probably even right now there is some company exploiting a loophole in some regulation as I type. As far as the drugs go, there are already regulations in place.
As for regulations doing nothing to prevent bad behavior, when is the last time a drug company released a drug into the US market without adequate testing and pulled it due to easily anticipated consequences that would have shown up in the studies they never conducted? This is exactly the behavior your proposed changes in the rules would allow, that I suggest needs to be prevented. As far as I can tell the FDA rules have successfully prevented this.