My major fetish is anal play, having either a strapon or a plug in my ass whenever possible.
My second, and older fetish, is being shackled and caged. I've had this fetish since my teen years and during my summer vacations I would find a way to tie myself up (still giving me a way to escape my crude bonds).
Another, lesser fetish of mine is pony play, however this one isn't nearly as much of a turn on as the other two.
EDIT: Also, Kidnapping and rape fantasies are a HUGE turn on for me. Probably moreso than even anal play.