It works both ways, too. I talked online a while back to a male sub who thought he was immune just because he was male and the Domme was a "tiny little thing."

He was tied up by the tiny little thing in a hotel room and she let in her boyfriend. The maid found him the next morning still tied quite nicely--minus his wallet and car keys. One hard limit until you're sure is that if bondage occurs, it's never more than two limbs.