I as a sub have never had the three together. I know for a fact my Master doesn't need to tie me up to cause me pain or humiliation. For example the first time he ever fisted my pussy he did not have me tied up in anyway and expected me to lay there calmly as he inserted his fist. And I can tell you it was hard to lay there for the pain was great and i was near tears by the time it was over. Humiliation is a tool that goes on its one and does not need anything to acompany it in the least. Though being humiliated while tied up and induring pain does work a Master/Mistress who knows what he or she is doing doesn't need to combine things to make them work.