There are a few things in there that concern me, the biggest being the conflicting messages you're getting from your domme (pillow-talk versus "regular" conversations). You should be able to explain to her the confusion this causes you and that you need more clarity as to what her intentions are. Maybe she is just playing mind games with you, but for you that isn't what you need; it is hard to trust a person when they purposefully mislead you like that.

she has successfully alienated me from my female friends
This to me is a red flag. The only reason I've known people to do this is because they don't trust. If you want to choose to break ties with people you know in order to be with her, that's okay if it's your choice. But you shouldn't be forced into it.

I have a weird feeling that it's almost like I'm making a deal with the devil. It's like I would be telling her: make me an accomplished artist, quench my thirst for perversions... and in exchange I will be your total slave, forever.
Pay attention to those "weird feelings". They are trying to tell you something. Pay attention to figure out what it is. It might be something totally repairable. Maybe you're just moving too far, too fast, and you can ask her to slow down. Maybe you're crossing a line you don't want to cross, and you can ask her to take a step back. Or maybe you're ignoring something that's blatantly wrong so you can get what you want. Whatever it is, you should be able to talk with her about this. A good domme will care about your feelings and will want to adjust the relationship so that both of your are happy. You should feel "right" and "whole" and any number of good things. You used the word "evil" a lot in your post. That's not...good.

Only you can know if this relationship is right for you. If you're feeling like you're giving up too much, then you are. You should be able to talk with her about this and work at finding the right balance of power that works for you. Discovering this in a new relationship is difficult and takes time.

should I be very careful and tentative about the power I give her,
or should I wake up let loose and realize that I'm one hell of an extremely lucky guy and eventually surrender to her?
I kinda feel like you're asking us to know by the third date whether you will marry this person someday. That's the kind of question only time can tell; but keep in mind that even if you do decide to "surrender", that it's not forever. You can always pull the plug, take yourself back, and leave. Of course the scary part is that usually hurts a lot.